How to make Hand Sanitizer at Home for Coronavirus (COVID-19)?(+Easy method)

        Hand sanitizer is important to fight against the virus and germs. Coronavirus (COVID-19) spread in a faster way by touching. The palm of our hand is the best place for a microorganism growth environment. There is no medicine for Coronavirus (COVID-19) yet. we can control the spreading by using certain types of precautions. How to make Hand Sanitizer at Home to kill coronavirus easy with aloe vera and alcohol? In this post, we discuss the formulation and chemical composition of hand sanitizer (easy method).

         Hand wash with sanitizer is one of the types of precaution measures for the cleanliness of hand. Even the doctor can't wear gloves for 24X7, it is not possible. Most people unaware of the method of hand wash. The composition of hand sanitizer is different from soap.

Hand Sanitizer -  Image by  from Pixabay

What is the difference between soap and hand sanitizer?

   The main difference between soap and hand sanitizer as follows

•     Soap is solid in nature. But hand sanitizer liquid in nature.
•     It is easy to use hand sanitizer as compare with soild soap more             frequently.
•     Soap solution creates hand etching. Hand sanitizer won't create             hand etching.
•     Soap solution is more alkaline in nature. Hand sanitizer weak acidic        or near neutral pH.
•     Hand sanitizer spread throughout the hand as compare with                     soap solution.
•     Hand sanitizer are more effective as compare to soap solution.

At first, we will discuss the formulation for hand sanitizer as per the recommendation of World Health Organisation (WHO), as given below.How to make Hand Sanitizer at Home easy?

Wash hand with hand sanitizer- Image by  from Pixabay

Formulation for Hand Sanitizer I

        The chemical composition for hand sanitizer is with the following chemical in proper proportions. Hand sanitizer composition to produce with the final concentration of ethanol 75-80% v/v, glycerol 1-1.45% v/v, hydrogen peroxide (H₂O₂) 0.5-0.125% v/v. v/v means, the volume of particular chemical in percentage divided with the total volume of solution preparation.

Preparation of Hand Sanitizer into a 1000 ml graduated flask or glass beaker:

1. Ethanol or Ethyl Alcohol 96- 99% v/v, 800 - 833.3 ml
2. Hydrogen peroxide (H₂O₂) 2-3% v/v, 38 - 41.7 ml
3. Glycerol 96-98% v/v,14.5 ml

        Finally, make up the flask or beaker to 1000 ml with distilled water (DM water) or water that has been boiled, filtered and cooled; shake the flask gently to mix the contents of the solution. Hand sanitizer should be in the homogeneous form.

       If you are able to buy these chemicals from a druggist or Online marketplace, you will readily get all these items. But you want to use the material available from the home. You can follow the following protocol.

• If Ethanol or Ethyl Alcohol is not available, you can use shaving lotion.
• If Hydrogen peroxide (H₂O₂) is not available, you can use ear cleaner in that place.
• If glycerol is not available, then you can use fash cleaning gel or aloe vera gel.

        In this way, you can make a hand sanitizer from home for the shortage of times in the marketplace. If there is an outbreak such as coronavirus, then you can make your hand sanitizer from the home. This particular composition is useful all types of germs (For example, SARS virus, Coronavirus (COVID-19), bacterial infection etc). How to make Hand Sanitizer at Home easy by using the above given compositions?

Formulation For Hand Sanitizer II

        The chemical composition for hand sanitizer is with the following chemical in proper proportions. Hand sanitizer composition to produce with the final concentration of Isopropyl Alcohol 65-75% v/v, glycerol 1-1.45% v/v, hydrogen peroxide (H₂O₂) 0.5-0.125% v/v. v/v means, the volume of particular chemical in percentage divided with the total volume of solution preparation. How to make Hand Sanitizer at Home easy by using below given compositions?

Preparation of Hand Sanitizer into a 1000 ml graduated flask or glass beaker:

1. Isopropyl Alcohol (with a purity of 99.8%), 680 - 751.5 ml
2. Hydrogen peroxide (H₂O₂ ) 3%, 38 - 41.7 ml
3. Glycerol 96- 98%, 14.5 ml

        Finally, make up the flask or beaker to 1000 ml with distilled water (DM water) or water that has been boiled, filtered and cooled; shake the flask gently to mix the contents of the solution. Hand sanitizers should be in a homogeneous form. This particular chemical composition is useful all types of germs (For example, SARS virus, Coronavirus (COVID-19), bacterial infection etc).

Image by Pete Linforth from Pixabay

Formulation for Hand Sanitizer III

          The chemical composition for hand sanitizer is with the following chemical in proper proportions in addition of silver ion (anti-viral agent). Hand sanitizer composition to produce with the final concentration of ethanol 75-80% v/v, glycerol 1-1.45% v/v, hydrogen peroxide (H₂O₂) 0.5-0.125% v/v and silver nitrate (AgNO₃) 0.5-0.1% w/w.

         v/v means, the the volume of particular chemical in percentage divided with the total the volume of solution preparation. w/w means, the weight of any chemical in percentage divided with the total weight of solution in percentage. The density of water is one. Water's volume is equal to weight.

Preparation of Hand Sanitizer into a 1000 ml graduated flask or glass beaker:

1. Ethanol or Ethyl Alcohol 96- 99% v/v, 800 - 833.3 ml
2. Hydrogen peroxide (H₂O₂) 2-3% v/v, 38 - 41.7 ml
3. Glycerol 96-98% v/v,14.5 ml
4. Silver nitrate 99% w/w, 100 mg or 0.1g

        Finally, makeup the flask or beaker to 1000 ml with distilled water (DM water) or water that has been boiled, filtered and cooled; shake the flask gently to mix the contents of the solution. Hand sanitizer should be in the homogeneous form.

  

Formulation For Hand Sanitizer IV

       The chemical composition for hand sanitizer is with the following chemical in proper proportions with addition of silver ion (anti-viral gent). Hand sanitizer composition to produce with the final concentration of Isopropyl Alcohol 65-75% v/v, glycerol 1-1.45% v/v, hydrogen peroxide (H₂O₂) 0.5-0.125% v/v and silver nitrate (AgNO₃) 0.5-0.1% w/w.

v/v means, the volume of particular chemical in percentage divided with the total volume of solution preparation. How to make Hand Sanitizer at Home easy by using below given compositions?

Preparation of Hand Sanitizer into a 1000 ml graduated flask or glass beaker:

1. Isopropyl Alcohol (with a purity of 99.8%), 680 - 751.5 ml
2. Hydrogen peroxide (H₂O₂ ) 3%, 38 - 41.7 ml
3. Glycerol 96- 98%, 14.5 ml
4. Silver nitrate 99% w/w, 100 mg or 0.1g

      Finally, make up the flask or beaker to 1000 ml with distilled water (DM water) or water that has been boiled, filtered and cooled; shake the flask gently to mix the contents of the solution. Hand sanitizers should be in a homogeneous form. This particular chemical composition is useful all types of germs (For example, SARS virus, Coronavirus (COVID-19), bacterial infection etc).

Why we need a hand sanitizer to kill coronavirus (COVID-19)?

          Before answer this question, we need to know about the basic biology of eukaryote cell and virus or coronavirus (COVID-19) surface morphology. First, eukaryote cell surface is made by a lipid bilayer. Lipids are nothing but cholesterol. Further, it can be classified into low density cholesterol lipid (LDC-lipid) and High Density Cholesterol lipid (HDC- lipid). Among these, High density cholesterol is good one which is soluble in water. But low density cholesterol is not soluble in water.

Image by Gerd Altmann from Pixabay

         Lipid is very similar to a surfactant molecule. In a surfactant molecule, it has a long chain with one or more non-polar end (not soluble in water) and polar end (soluble in water). These surfactant molecules at particular concentration creates micelles. This concentration is called Critical Micellar Concentration (CMC). But lipid creates bilayer with a capsule like structure in eukaryote cell and virus or coronavirus (COVID-19).

         Moreover, if the non-polar end is long, it is called low density cholesterol lipid (LDC-lipid). If the non-polar end is short in range, it is called High Density Cholesterol lipid (HDC- lipid). Eukaryote cell and virus or coronavirus (COVID-19) capsule surface contain active proteins. In a eukaryote cell, it is called G-coupled proteins and ion channels. Similarly, you can see more spikes of active proteins in the surface of virus or coronavirus (COVID-19).

       Finally, two method is possible to kill coronavirus (COVID-19) in room temperature. First method, surfactant molecule of soap solution or hand wash to break the coronavirus (COVID-19) lipid bilayer. It need 20 to 30 seconds to kill coronavirus (COVID-19). In second method, hand sanitizer to deactivate or denature the surface protein of coronavirus (COVID-19). This denaturing of protein reaction takes place with in 2-3 seconds. Hand sanitizer is much faster reactivity towards coronavirus (COVID-19) than hand wash and soap solution.

   You can see more antiviral character of silver ion on coronavirus in our previous post.

Reference:

1. L- histidine molecule based hydrogel(WO2019021143A)
2. Process of preparation of l-histidine molecule based hydrogel by gelation of water(WO2019021144A1)
3. Liquid composition comprising histidine-silver complex, germicidal agent composition, and method for stabilization of histidine-silver complex (WO2009098850A1)
4. Method for maintaining microbicidal activity of histidine-silver complex in chlorine-ion-containing solution, and liquid antimicrobial composition(WO2012144475A1)
5. Anti-coronavirus agent (EP1676582B1)
6. Material safety data sheet of Silver nitrate (AgNO₃)

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